top of page
Selected Journal articles

  1. Zhang X, Luo Y, Hao H, Krahn, J, Su G, Dutcher R, Xu Y, Liu J, Pedersen LC, Ding Xu (2024). Heparan sulfate selectively inhibits the collagenase activity of cathepsin K. Matrix Biology. 2024 May:129:15-28. doi: 10.1016/j.matbio.2024.03.005

  2. Chihyean Ong, Miaomiao Li, Ding Xu (2023). Development of mAbs that block the heparan sulfate binding site of receptor for advance glycation end-product (RAGE). Glycobiology.

  3. Yin Luo, Huanmeng Hao, Zhangjie Wang, Chihyean Ong, Robert Dutcher, Yongmei Xu, Jian Liu, Lars C. Pedersen and Ding Xu (2023). Heparan sulfate promotes TRAIL-induced tumor cell apoptosis. eLife.

  4. Yin Luo, Miaomiao Li and Ding Xu (2022). A disease-causing human osteoprotegerin mutant exists in hyper-oligomerized forms. Scientific Report. 2022 Sep 10;12(1):15279.  doi: 10.1038/s41598-022-19522-9.

  5. Miaomiao Li, Chih Yean Ong, Christophe J Langouët-Astrié, Lisi Tan, Ashwni Verma, Yimu Yang, Xiaoxiao Zhang, Dhaval K. Shah, Eric P. Schmidt and Ding Xu (2022). Heparan Sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE. eLife. 2022;11:e71403 DOI: 10.7554/eLife.71403. 

  6. Xiaoxiao Zhang, Xinyue Liu, Miaomiao Li, Guowei Su, Jian Liu, Chunyu Wang, and Ding Xu (2021).  pH-Dependent and Dynamic Interactions of Cystatin C with Heparan Sulfate. Communications Biology 4(1):198. doi: 10.1038/s42003-021-01737-7. 

  7. Miaomiao Li & Ding Xu (2020). Antiresorptive activity of osteoprotegerin requires an intact heparan sulfate-binding site. PNAS. doi: 10.1073/pnas.2005859117. PMID: 32636266

  8. Arnold K, Xu Y, Sparkenbaugh EM, Li M, Han X, Zhang X, Xia K, Piegore M, Zhang F, Zhang X, Henderson M, Pagadala V, Su G, Tan L, Park PW, Stravitz RT, Key NS, Linhardt RJ, Pawlinski R, Xu D# and Liu J#. Design of anti-inflammatory heparan sulfate to protect against acetaminophen-induced acute liver failure. Science Transl Med (2020). Mar 18;12(535). PMID 32188725.    #corresponding authors

  9. Zhang X, Ong C, Su G, Liu J, Xu D. Characterization and Engineering of S100A12–Heparan sulfate interactions. Glycobiology. (2020) doi: 10.1093/glycob/cwz111. PubMed PMID: 31942981 

  10. Yiming Xiao, Miaomiao Li, Rinzhi Larocque, Fuming Zhang, Anju Malhotra, Jianle Chen, Robert J. Linhardt, Lars Konermann, and Ding Xu (2018). Dimerization Interface of Osteoprotegerin Revealed by Hydrogen-deuterium Exchange Mass Spectrometry. J Biol Chem 293 (45), 17523-17535. PMID: 30254073.

  11. Miaomiao Li, Shuying Yang, Ding Xu* (2016). Heparan Sulfate Regulates the Structure and Function of Osteoprotegerin in Osteoclastogenesis . J Biol Chem 291 (46):24160-24171. PMID: 27697839.

On the horizon
  1. Yin Luo, Xiaoxiao Zhang, Ding Xu (2024). Heparan sulfate regulates cathepsin K-mediated bone resorption in vivo. In preparation

  2. Chihyean Ong, Ding Xu (2024). Heparan sulfate-BMPER interaction is required for normal bone homeostasis. In preparation

  3. Huanmeng Hao, Ding Xu (2024). Heparan sulfate promotes procathepsin K autoactivation by disruption the stability of the pro-peptide domain. In preparation

Selected Review articles

  1. Miaomiao Li, Lars C. Pedersen, Ding Xu (2023). Targeting heparan sulfate-protein interactions with oligosaccharides and monoclonal antibodies. Frontiers Mol Biosci 2023 May 19;10:1194293. PMID: 37275960.

  2. Ding Xu and Jeffrey D. Esko (2014). Demystifying Heparan sulfate-binding proteins. 2014;83:129-57. Annual Review of Biochemistry.  PMID: 24606135

  3. Xu D, Arnold K, Liu J. Using structurally defined oligosaccharides to understand the interactions between proteins and heparan sulfate. Curr Opin Struct Biol. 2018 Apr 20;50:155-161. doi: 10.1016.  PMID: 29684759. 

bottom of page